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State Level Eligibility Test

SLET: Life Sciences

Code No. : 04
Subject : LIFE SCIENCES
PAPER III

27. Energy metabolism (concept of free energy); Thermodynamic principles in biology; Energy rich bonds; Weak interactions; Coupled reactions and oxidative phosphorylations; Group transfers; Biological energy transducers; Bioenergetics.

28. Fine structure of gene; Eukaryotic genome organisation(structure of chromatic, coding and non coding sequences, satellite DNA); DNA damage and repair; DNA replication, amplification
and rearrangements.

29. Organization of transcriptional units; Mechanism of transcription of prokaryoies and eukaryotes; RNA processing (capping, polyadenylation, splicing, introns and exons); Ribonucleoproteins; Structure of mRNA; Genetic code and protein synthesis.

30. Regulation of gene expression in pro- and eukaryotes; Attenuation and antitermination; Operon concept; DNA methylation; Heterochromatization; Transposition; Regulatory sequences and transacting factors; Environmental regulation of gene expression.

31. Biochemistry and molecular biology of cancer; Oncogenes; Chemical carcinogenesis; Genetic and metabolic disorders; Hormonal imbalances; Drug metabolism and detoxification; Genetic load and generic counselling.

32. Lysogeny and lytic cycle in bacteriophages; Bacterial transformation; Host cell restriction; Transduction; Complementation; Molecular recombination; DNA ligases; Topoisomerases; Gyrases; Methylases; Nucleases; Restriction endonucleases; Plasmids and bacieriophage based vectors for cDNA and genomic libraries.